SMAD2 Protein, Human, Recombinant (His & SUMO)

Product Overview

• Article Name: SMAD2 Protein, Human, Recombinant (His & SUMO)
• Biozol Catalog Number: TGM-TMPH-01699
• Supplier Catalog Number: TMPH-01699
• Alternative Catalog Number: TGM-TMPH-01699-1MG,TGM-TMPH-01699-5UG,TGM-TMPH-01699-10UG,TGM-TMPH-01699-20UG,TGM-TMPH-01699-50UG,TGM-TMPH-01699-100UG,TGM-TMPH-01699-200UG,TGM-TMPH-01699-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: SMAD2 , MAD homolog 2 , Mothers against decapentaplegic homolog 2 , Mothers against DPP homolog 2 , Mad-related protein 2 (hMAD-2) , MADH2 , SMAD family member 2 (SMAD 2,Smad2,hSMAD2) , JV18-1 , MADR2

Product Description

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Images

TMPH-01699