Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
Molekulargewicht:
4200.93
CAS Nummer:
[230299-95-3]
Formel:
C185H304N68O43S
Target-Kategorie:
Apelin receptor|||HIV Protease
TP2094
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