TRV-120027 TFA is an angiotensin II-mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a beta-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R-beta-arrestin-1-TRPC3-PLCgamma at the plasma membrane.
Molekulargewicht:
1040.1
Reinheit:
97.45%
Formel:
C45H68F3N13O12
Target-Kategorie:
TRP/TRPV Channel|||RAAS|||Arrestin
TP2158
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