ST-CY14 is an inhibitor of the Nur77-PPARgamma interaction with an EC50 of 3.15 µM. It binds to Nur77 (Kd=32 nM) to prevent its ubiquitination and degradation by PPARgamma, reducing fatty acid uptake and mitochondrial respiration, and inhibiting the transcription of CD36 and FABP4. ST-CY14 suppresses proliferation and migration of MCF7 and MDA-MB-231 cancer cells and impedes tumor growth and bone metastasis in mouse models.
Molekulargewicht:
3266.86
Formel:
C139H237N57O31S2
Target-Kategorie:
Mitochondrial Metabolism|||NR4A
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
