ST-CY14 is an inhibitor of the Nur77-PPARgamma interaction with an EC50 of 3.15 µM. It binds to Nur77 (Kd=32 nM) to prevent its ubiquitination and degradation by PPARgamma, reducing fatty acid uptake and mitochondrial respiration, and inhibiting the transcription of CD36 and FABP4. ST-CY14 suppresses proliferation and migration of MCF7 and MDA-MB-231 cancer cells and impedes tumor growth and bone metastasis in mouse models.
Molecular Weight:
3266.86
Formula:
C139H237N57O31S2
Target:
Mitochondrial Metabolism|||NR4A
* VAT and and shipping costs not included. Errors and price changes excepted
