NAB815 is a specific inhibitor of Stx2a (Kd= 0.01 µM)/TLR4 interactions. It inhibits the interaction between neutrophils and Stx2a with an IC50 of 0.057 µg/mL. NAB815 also prevents the formation of extracellular vesicles (EV) containing Stx2 from leukocytes and platelets, reducing its toxicity in cells (Vero cells) and in animal models (CD-1 mice). Additionally, NAB815 decreases the bacterial load in the kidneys, urine, and bladder of mice infected with Escherichia coli. It is applicable for research in hemolytic uremic syndrome (HUS).
Molekulargewicht:
1175.42
CAS Nummer:
[1969250-99-4]
Formel:
C55H94N14O14
Target-Kategorie:
Antibacterial|||TLR
TP3879
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
