NAB815 is a specific inhibitor of Stx2a (Kd= 0.01 µM)/TLR4 interactions. It inhibits the interaction between neutrophils and Stx2a with an IC50 of 0.057 µg/mL. NAB815 also prevents the formation of extracellular vesicles (EV) containing Stx2 from leukocytes and platelets, reducing its toxicity in cells (Vero cells) and in animal models (CD-1 mice). Additionally, NAB815 decreases the bacterial load in the kidneys, urine, and bladder of mice infected with Escherichia coli. It is applicable for research in hemolytic uremic syndrome (HUS).
Molecular Weight:
1175.42
CAS Number:
[1969250-99-4]
Formula:
C55H94N14O14
Target:
Antibacterial|||TLR
TP3879
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