Breceptin (B 9870) serves as an antagonist and partial agonist for bradykinin B1/B2 receptors (B1/B2R). In rabbit jugular vein contraction assays, it functions as an irreversible B2R antagonist, inhibiting bradykinin-induced vasoconstriction. B-9870 exhibits partial agonist characteristics in HEK 293 cells with high rabbit B2R expression, activating ERK1/2 phosphorylation, calcium mobilization, arachidonic acid release, and receptor internalization. Breceptin is applicable in research on breast cancer and non-small cell lung cancer inhibition.
Molekulargewicht:
2815.33
CAS Nummer:
[215713-39-6]
Formel:
C136H200N38O28
Target-Kategorie:
ERK|||Bradykinin Receptor
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
