Breceptin (B 9870) serves as an antagonist and partial agonist for bradykinin B1/B2 receptors (B1/B2R). In rabbit jugular vein contraction assays, it functions as an irreversible B2R antagonist, inhibiting bradykinin-induced vasoconstriction. B-9870 exhibits partial agonist characteristics in HEK 293 cells with high rabbit B2R expression, activating ERK1/2 phosphorylation, calcium mobilization, arachidonic acid release, and receptor internalization. Breceptin is applicable in research on breast cancer and non-small cell lung cancer inhibition.
Molecular Weight:
2815.33
CAS Number:
[215713-39-6]
Formula:
C136H200N38O28
Target:
ERK|||Bradykinin Receptor
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