Vemurafenib, Free Base (PLX4032), CAS [[918504-65-1]]

Produktübersicht

• Artikelname: Vemurafenib, Free Base (PLX4032), CAS [[918504-65-1]]
• Artikelnummer: USB-022761
• Hersteller Artikelnummer: 022761
• Alternativnummer: USB-022761-25,USB-022761-50,USB-022761-100
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Vemurafenib selective BRAFV600E kinase inhibitor, an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Appearance: Cyrstalline solid Purity: 99% (HPLC) 99% (TLC) Melting Point: 269-270.5C Method for Determining Identity: Proton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis Solubility: Soluble in DMSO at 100mg/mL, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 25-50uM, buffers, serum, or other additives may increase or decrease the aqueous solubility Storage: Store at or below -20C. Note: As of September 2011 the current correct CAS number for vemurafenib, also known as PLX4032, is given above. Chemical Abstracts Service recently canceled another CAS number, 1029872-54-5, that had previously been used for vemurafenib under its older name, PLX4032. However, this canceled number remains in wide use and receives the vast majority of hits on Google.

Produkteigenschaften

• Molekulargewicht: 489.92
• Reinheit: 99% (HPLC), 99% (TLC)
• Formulierung: Cyrstalline solid
• CAS Nummer: [918504-65-1]