Vemurafenib, Free Base (PLX4032), CAS [[918504-65-1]]
Biozol Catalog Number:
USB-022761
Supplier Catalog Number:
022761
Alternative Catalog Number:
USB-022761-25,USB-022761-50,USB-022761-100
Manufacturer:
US Biological
Category:
Biochemikalien
Vemurafenib selective BRAFV600E kinase inhibitor, an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Appearance: Cyrstalline solid Purity: 99% (HPLC) 99% (TLC) Melting Point: 269-270.5C Method for Determining Identity: Proton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis Solubility: Soluble in DMSO at 100mg/mL, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 25-50uM, buffers, serum, or other additives may increase or decrease the aqueous solubility Storage: Store at or below -20C. Note: As of September 2011 the current correct CAS number for vemurafenib, also known as PLX4032, is given above. Chemical Abstracts Service recently canceled another CAS number, 1029872-54-5, that had previously been used for vemurafenib under its older name, PLX4032. However, this canceled number remains in wide use and receives the vast majority of hits on Google.
Molecular Weight:
489.92
Purity:
99% (HPLC), 99% (TLC)
Form:
Cyrstalline solid
CAS Number:
[918504-65-1]
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