Rimacalib, a inhibitor of CaMKII, inhibits VEGF expression in human acute monocytic leukemia cell and SF macrophage obtained from patient with rheumatoid arthritis. This effect may contribute to the anti-arthritic effects of Rimacalib. The IC50s of Rimacalib are ~1uM for CaMKIIalpha to ~30uM for CaMKIIgamma. Synonyms: SMP 114, N-[3-[(1S)-1-(2-Fluoro[1,1-biphenyl]-4-yl)ethyl]-5-isoxazolyl]-4-morpholinecarboximidamide CAS No: 215174-50-8 HCl Salt: 215174-78-0 Molecular Formula: C22H23FN4O2 Molecular Weight: 394.44 Appearance: Supplied as a off-white to pale orange solid Purity: 99% Melting Point: >56C (dec.) Solubility: Chloroform (Slightly), Methanol (Slightly), DMSO (125mg/ml) Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
394.44
Reinheit:
99%
Formulierung:
Supplied as a off-white to pale orange solid
CAS Nummer:
[215174-50-8]
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