Von Hippel-Lindau Protein (vHL), Clone: [3F391], Mouse, Monoclonal

Produktübersicht

• Artikelname: Von Hippel-Lindau Protein (vHL), Clone: [3F391], Mouse, Monoclonal
• Artikelnummer: USB-V2640-02
• Hersteller Artikelnummer: V2640-02
• Alternativnummer: USB-V2640-02-500
• Hersteller: US Biological
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: ELISA
• Immunogen: Recombinant protein containing aa1-213 of human Von Hippel-Lindau Protein (vHL). Epitope: aa1-54. Cellular Localization: Cytoplasmic.

Produktbeschreibung

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (vHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC) and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [3F391]
• Reinheit: Purified by Protein G affinity chromatography from ascites.
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.