Von Hippel-Lindau Protein (vHL), Clone: [3F391], Mouse, Monoclonal
Biozol Catalog Number:
USB-V2640-02
Supplier Catalog Number:
V2640-02
Alternative Catalog Number:
USB-V2640-02-500
Manufacturer:
US Biological
Host:
Mouse
Category:
Antikörper
Application:
ELISA
Immunogen:
Recombinant protein containing aa1-213 of human Von Hippel-Lindau Protein (vHL). Epitope: aa1-54. Cellular Localization: Cytoplasmic.
Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (vHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC) and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clonality:
Monoclonal
Clone Designation:
[3F391]
Purity:
Purified by Protein G affinity chromatography from ascites.
Form:
Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
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