MRK003 is a gamma-secretase inhibitor demonstrating potent preclinical activity against multiple myeloma and non-Hodgkins lymphoma cell lines and patient samples. It induces caspase-dependent apoptosis, modulates key proteins like Notch, c-Myc, and Bcl-2 family members, and shows crosstalk with the PI3K/Akt pathway, supporting its use in oncology research for in vitro mechanism of action studies.
Molecular Weight:
551.59
CAS Number:
[623165-93-5]
Formula:
C25H31F6N3O2S
Target:
Apoptosis,Others,Gamma-secretase
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