JB-1, an IGF-I analog, is a selective IGF-I receptor inhibitor that does not interact with IGF-II. JB-1 competes with IGF-I for binding to IGF-1R and blocks receptor autophosphorylation. JB-1 increases the level of sVEGFR-1. JB-1 normalizes retinal abnormalities, including reducing retinal neovascularization. JB-1 is applicable to studies related to oxygen-induced retinopathy[1].
Molecular Weight:
1249.50
Purity:
99.63
CAS Number:
[147819-32-7]
Formula:
C55H88N14O15S2
Target:
Drug Derivative,IGF-1R,VEGFR
Application Notes:
MCE Product type: Peptides
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