Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of [1]. Dasatinib monohydrate also induces apoptosis and autophagy.
Molecular Weight:
506.02
Purity:
99.58
CAS Number:
[863127-77-9]
Formula:
C22H28ClN7O3S
Target:
Apoptosis,Autophagy,Bcr-Abl,Src
Application Notes:
Reference compound
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