Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-B signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells[1][2][3][4][5][6].
Molecular Weight:
720.71
Purity:
99.06
CAS Number:
[11141-17-6]
Formula:
C35H44O16
Target:
Apoptosis,Bcl-2 Family,Caspase,NF-kappaB,Parasite
Application Notes:
Natural Products
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