CD23 (Low Affinity Immunoglobulin epsilon Fc Receptor, BLAST-2, C-type Lectin Domain Family 4 Member J, Fc-epsilon-RII, Immunoglobulin E-binding Factor, Lymphocyte IgE Receptor, FCER2, CD23A, CLEC4J, FCE2, IGEBF), Rabbit
Biozol Catalog Number:
USB-C2274-06B
Supplier Catalog Number:
C2274-06B
Alternative Catalog Number:
USB-C2274-06B-50
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
IHC
Immunogen:
Recombinant corresponding to aa48-248 from human FCER2.
CD23 is a 45kD protein, also known as Leu-20, FcERII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-a, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6aa in their cytoplasmic region. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 15ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity:
Purified by immunoaffinity chromatography.
Form:
Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
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