CDC2 (Cell Division Protein Kinase , CDK1, Cyclin-dependent Kinase 1, Cell Division Control Protein 2 Homolog, p34 Protein Kinase), Rabbit
Biozol Catalog Number:
USB-C2571-07J
Supplier Catalog Number:
C2571-07J
Alternative Catalog Number:
USB-C2571-07J-50
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Immunogen:
Synthetic peptide corresponding to aa surrounding Tyrosine 15 from human CDC2 (KLH).
CDC2/CDK1, a CDC2/CDK -type protein kinase, regulates cell cycle transitions G1 to S and G2 to M. CDC2/CDK1 is maintained in an inactive state by phosphorylation by kinases MYT1 and WEE1. The active kinase, called the M-phase promoting factor, consists of a heterodimer with cyclin B, and final activation at G2/M results from CDC25 phosphatase-mediated dephosphorylation of CDC2/CDK1. The drug Taxol has been shown to activate CDC2/CDK1 in MDA-MB-435 breast cancer cells, leading to cell cycle arrest at G2/M and to apoptosis. CDC2 has also been implicated in neurofibrillary degeneration in Alzheimers disease and other neurodegenerative diseases. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity:
Purified by immunoaffinity chromatography.
Form:
Supplied as a liquid in PBS, 0.02% sodium azide, 50% glycerol.
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