Anti-Botulinum neurotoxin type A [CR1], Human Fab fragment, His-Tagged, kappa, Monoclonal
Biozol Catalog Number:
ABA-AB00803-10.6-BS
Supplier Catalog Number:
Ab00803-10.6-BS
Alternative Catalog Number:
ABA-AB00803-10.6-BS
Manufacturer:
Absolute Antibody
Host:
Human
Category:
Antikörper
Application:
FC, NeA
Species Reactivity:
Clostridium
Alternative Names:
BoNT/A, BoNT, Botulinum neurotoxin, Bontoxilysin-A, Bontoxilysin A, BOTOX
CR1 was produced by a yeast gene diversity library used to increase the affinitiy of scFv AR2 for BoNT/A2, while maintinaing high affinity binding to BoNT/A2. AR2 was generated after multiple rounds of affinity maturation of the humanized C25, which itself was created by CDR-grafting from the parental murine C25. Murine C25 was prepared by constructing a scFv phage display library from mice immunized with recombinant BoNT/A binding domain (Hc).
