IARC-307, TCR-beta, T cell receptor, T-cell receptor, T cell receptor beta chain, TCRB, TRB, TCB1, Ti, TCR V beta, IARC/307, IARC 307
Derived from normal B cells in peripheral blood of a Burkitts lymphoma patient. Screened more than 60 culture supernatants from lymphoblastoid cell lines of normal origin, Epstein-Barr virus (EBV)-carrying Burkitt lymphomas, EBV-negative Burkitt lymphomas and EBV-converted sublines of original EBV-negative Burkitt lymphoma human B-cell lines for their capacity to bind the synthetic peptide autoantigens. One lymphoblastoid B-cell line was identified, IARC307, that produces IgM kappa antibodies which specifically react with the CDR1 peptide corresponding to human Vbeta8.1 gene sequence.
