Anti-MOG [M3-31], Human IgG1, kappa, Monoclonal
Catalog Number:
ABA-AB01208-10.0
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| Article Name: | Anti-MOG [M3-31], Human IgG1, kappa, Monoclonal |
| Biozol Catalog Number: | ABA-AB01208-10.0 |
| Supplier Catalog Number: | Ab01208-10.0 |
| Alternative Catalog Number: | ABA-AB01208-10.0 |
| Manufacturer: | Absolute Antibody |
| Host: | Human |
| Category: | Antikörper |
| Application: | Blocking, ELISA, IHC |
| Species Reactivity: | Human, Rat |
| Alternative Names: | Myelin oligodendrocyte glycoprotein, rMOG, hMOG |
| Callithrix jacchus marmosets were used, and experimental allergic encephalomyelitis was induced by the injection of rat MOG (aa1-125) into the marmosettes. The rMOG was expressed in E. coli and purified to homogeneity. The animals were killed 4-70 days after the onset of symptoms of EAE. Bone marrow and spleen cells were obtained from an immunized C. jacchus, the RNA extracted with Trizol reagent and rtPCR used to generate cloning inserts containing Fab portions of IgGk. Phage display was then used to select for the MOG-reactive Fab fragments using the pCOMB3H phage display vector, and binding confirmed using an ELISA. |
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