Digoxin is a cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c, caspases 8 and 3.
Clonality:
Monoclonal
Purity:
Affinity purification
Sequence:
Digoxin conjugated to KLH
Target:
Digoxin
Application Dilute:
DB,1:500 - 1:3000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
Application Notes:
Cross-Reactivity: Species independent. Shipping: Ice Bag
The HRP-conjugated Digoxin Rabbit mAb (A24114) are tested in Dot Blot against digoxin labelled oligonucleotide(Dig-1,Dig-2 and Dig-3) and unlabelled oligonucleotide(Dig-4) . Dig-1(5AGCTAAC/T(Digoxin)/ACTAGCT(Bition)3) Dig-2(5(Digoxin)AGCTAACTACTAGCT(Bition)3) Dig-3(5(Bition)AGCTAACTACTAGCT(Digoxin)3) Dig-4(5AGCTAACTACTAGCT(Bition)3)
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