Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
PE/Cy7
Alternative Names:
ADPRC1, cADPR1, ADPRC 1
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Flow cytometry: 1X10 6 Human PBMC were surface-stained with PE/Cyanine7 Rabbit IgG isotype control (5 µl/Test,left) or PE/Cyanine7 Rabbit anti-Human CD38 mAb (A27401,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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