Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
PE
Alternative Names:
DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Flow cytometry: 1X10 6 Human PBMC (untreated, solid lines)and Human PBMC (treated with 5 ng/ml PMA and 500 ng Ionomycin in the presence of Brefeldin A for 4 hours, filled lines) were intracellularly-stained with PE Rabbit anti-Human TNF-alpha mAb (A27433,5 µl/Test,orange) or PE Rabbit IgG isotype control (A24172,5 µl/Test,blue).
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