Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
PE
Alternative Names:
Ctla4,Cd152,CTLA4
CD152, also known as CTLA-4 or Ly-56, is a 33 kDa member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 exhibits significant homology to CD28 in amino acid sequence, structural configuration, and genomic organization, with both receptors sharing ligands from the B7 family (B7-1 and B7-2). While CD28 delivers co-stimulatory signals during T cell activation, CTLA-4 functions as a critical negative regulator of cell-mediated immune responses. CD152 is implicated in the induction and maintenance of immune tolerance, the development of protective immunity, and the modulation of thymocyte homeostasis.
Flow cytometry: 1X10 6 BALB/c mouse splenocytes (untreated,left) and BALB/c mouse splenocytes (treated with 2.5 µg/ml ConA for 3 days,right) were surface-stained with FITC Anti-Mouse CD3e mAb (A23322) or PE Rabbit anti-Mouse CD152/CTLA-4 mAb (A27774,0.25ug).
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