Synthetic peptide. This information is considered to be commercially sensitive.
Conjugation:
ABflo 450
Alternative Names:
T3E, TCRE, IMD18, CD3epsilon
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Flow cytometry: 1X10 6 Human PBMC were intracellularly-stained with ABflo 450 Rabbit IgG isotype control (A27451,5 µl/Test,left) or ABflo 450 Rabbit anti-Human cCD3 mAb (A27836,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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