Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
APC
Alternative Names:
M130, MM130, SCARI1
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Flow cytometry:1X10 6 Human PBMC were surface-stained with ABflo 488 Rabbit anti-Human/Monkey CD14 mAb (A25071,5 µl/Test) and APC Mouse IgG1 isotype control (5 µl/Test,left) or APC Mouse anti-Human CD163 mAb (A27960,5 µl/Test,right). Cells in the monocyte gate were used for analysis.
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