The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Flow cytometry: 1X10 6 Human PBMC (untreated,left)and Human PBMC (treated with PHA for 3 days,right) were surface-stained with PE Rabbit anti-Human TIM-3/HAVCR2 mAb (A7986,5 µl/Test). Cells in the lymphocyte gate were used for analysis.
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