Synthetic peptide. This information is considered to be commercially sensitive.
Conjugation:
PE
Alternative Names:
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Cross-Reactivity: Human, ResearchArea: Signal Transduction,G protein signaling,G-Protein-Coupled Receptors Signaling to MAPK Erk,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology Inflammation,CDs,Neuroscience, Cell Type Marker,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells.
Flow cytometry:1X10 6 Human PBMC were surface-stained with APC Rabbit anti-Human CD14 mAb (A25937,5 µl/Test) and PE Mouse IgG1 isotype control (A22878,5 µl/Test,left) or PE Mouse anti-Human CD11b mAb (A28070,5 µl/Test,right). Cells in the monocyte gate were used for analysis.
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