Enables complement component C3b binding activity, heparan sulfate proteoglycan binding activity, and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development, endocytosis, and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation, leukocyte migration, and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system, heart, lymphatic vessel, thymus, and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).
Cross-Reactivity: Mouse. ResearchArea: Signal Transduction,Tags & Cell Markers,Neuroscience,Stem Cells. Shipping: Ice Bag
Flow cytometry: 1X10 6 C57BL/6 mouse bone marrow cells were surface-stained with Biotin Rabbit IgG isotype control (A25626,5 µl/Test,left) or Biotin Rabbit anti-Mouse CD11b mAb (A28130,0.25µg,right), followed by ABflo 488 Streptavidin staining.
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