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Conjugation:
Biotin
Alternative Names:
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Cross-Reactivity: Human. ResearchArea: Signal Transduction,G protein signaling,G-Protein-Coupled Receptors Signaling to MAPK Erk,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology Inflammation,CDs,Neuroscience, Cell Type Marker,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells. Shipping: Ice Bag
Flow cytometry: 1X10 6 Human PBMC were surface-stained with ABflo 488 Rabbit anti-Human CD14 mAb (A25071,5 µl/Test) and Biotin Mouse IgG1 isotype control (5 µl/Test,left) or Biotin Mouse anti-Human CD11b mAb (A28153,0.25 µg,right), followed by APC Streptavidin staining.
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