Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
ABflo 647
Alternative Names:
CD210, IL10R, CD210a, CDW210A, HIL-10R, IL-10R1
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Flow cytometry: 1X10 6 Human PBMC were surface-stained with ABflo 647 Rabbit IgG isotype control (A22070,5 µl/Test,left) or ABflo 647 Rabbit anti-Human IL-10RA/CD210 mAb (A28197,5 µl/Test,right). Cells in the lymphocyte and monocyte gates were used for analysis.
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