Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
ABflo 488
Alternative Names:
BSF1, IL-4, BCGF1, BSF-1, BCGF-1
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Flow cytometry: 1X10 6 Human PBMC (untreated,left) and Human PBMC (treated with 50ng/ml PMA + 1µg/ml Ionomycin + 2uM Monensin for 6 hours,right) were surface-stained with ABflo 450 Rabbit anti-Human CD4 mAb (A26523,5 µl/Test) , then intracellularly-stained with ABflo 488 Rabbit anti-Human IL-4 mAb (A28198,5 µl/Test).
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