Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
PE
Alternative Names:
CLEC4K
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
Cross-Reactivity: Human. ResearchArea: Cancer,Signal Transduction,Endocrine Metabolism,Immunology Inflammation,CDs. Shipping: Ice Bag
Flow cytometry: 1X10 6 Human PBMC (untreated,left) and Human PBMC (treated with 100 ng/mL GM-CSF, 20 ng/mL IL-4, and 40 ng/mL TGF-beta for 3 days, followed by an additional 3-day culture with GM-CSF and TGF-beta,right) were surface-stained with ABflo 488 Mouse anti-Human CD1a mAb (A26905,5 µl/Test) and PE Rabbit anti-Human CD207/Langerin mAb (A28251,5 µl/Test).
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