Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) is a 195 kDa transmembrane receptor tyrosine kinase. The VEGF receptor features seven extracellular immunoglobulin-like (Ig) domains, a single transmembrane domain, and a conserved intracellular tyrosine kinase domain. In adults, VEGFR3 expression is primarily restricted to lymphatic endothelial cells and is known to govern lymphangiogenesis. The binding of VEGF-C or VEGF-D to VEGFR3 induces trans-phosphorylation of tyrosine residues within its intracellular domain. This phosphorylation event facilitates the recruitment of downstream signaling molecules, ultimately leading to the activation of the ERK1/2 and Akt signaling cascades.
Cross-Reactivity: Human. ResearchArea: Angiogenesis, Cardiovascular, Kinase/Tyrosine kinases, Signal Transduction, Growth factors, Cancer,Invasion and Metastasis, Cell Biology, Developmental Biology, Cell Cycle. Shipping: Ice Bag
Flow cytometry: 1X10 6 MCF7 cells (low expression,left)and HEL cells (right) were were surface-stained with PE Rabbit anti-Human VEGFR-3/FLT-4 mAb (A28354,5 µl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 µl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
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