Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
PE
Alternative Names:
T8, Lyt2, Ly-2, CD8alpha
CD8a, a 32 kDa glycoprotein also known as T8, Lyt2, Ly-2, and CD8alpha, is a member of the immunoglobulin superfamily. It is expressed on most thymocytes, subsets of mature T cells, the majority of NK cells, macrophages, and some activated (non-resting) CD4+ T cells. CD8a forms a heterodimer with the CD8beta chain (CD8b) on the surface of most thymocytes. In contrast, mature peripheral T lymphocytes predominantly express the CD8 alphabeta heterodimer. Intestinal intraepithelial lymphocytes express CD8a but lack CD8b expression. CD8 functions as an antigen co-receptor on T cells, interacting with Major Histocompatibility Complex (MHC) class I molecules on antigen-presenting cells or epithelial cells. CD8 participates in T cell activation by associating with the T cell receptor (TCR) complex and the protein tyrosine kinase lck (p56lck).
Cross-Reactivity: Rat. ResearchArea: Immunology,Adaptive Immunity,T Cells,Cytotoxic Cells. Shipping: Ice Bag
Flow cytometry: 1X10 6 Rat splenocytes were surface-stained with PE Rabbit IgG isotype control (A24172,5 µl/Test,left) or PE Rabbit anti-Rat CD8a mAb (A28358,0.25 µg,right).
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