CD123 is the 70 kDa transmembrane alpha chain of the interleukin-3 (IL-3) receptor. It binds IL-3 with low affinity when alone, however, upon association with CD131 (the common beta chain), the complex binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon IL-3 binding and requires the beta chain for this function. CD123 is expressed on bone marrow precursor cells, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and certain B-cell populations.
Cross-Reactivity: Human. ResearchArea: Signal Transduction,Immunology Inflammation,CDs,Cytokines,Interleukins,Cell Intrinsic Innate Immunity Signaling Pathway. Shipping: Ice Bag
Flow cytometry:1X10 6 Human PBMC were surface-stained with APC anti-human CD45RO Antibody (5 µl/Test) and PE Rabbit IgG isotype control (A24172,5 µl/Test,left) or PE Rabbit anti-Human CD123 mAb (A28488,5 µl/Test,right). Cells in the lymphocyte gate were used for analysis.
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