Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
FITC
Alternative Names:
Lca, RT7, CD45, L-CA, T200
CD45 is a 180-220 kDa protein, also known as the Leukocyte Common Antigen (LCA). It is a protein tyrosine phosphatase that exists in multiple isoforms generated by alternative splicing of exons within the extracellular domain and differential glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets, the expression of specific isoforms depends on cell type, activation status, and maturation stage. It is essential for signal transduction through the T-cell and B-cell antigen receptors. CD45 has been shown to interact with various proteins, including galectin-1, CD2, CD3, and CD4. The OX-1 antibody has been demonstrated to partially inhibit NK cell-mediated lysis of syngeneic tumor cells in vitro.
Cross-Reactivity: Rat. ResearchArea: Signal Transduction,Cell Biology Developmental Biology,Immunology Inflammation,CDs,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Cell Type Marker,Hematopoietic Progenitors. Shipping: Ice Bag
Flow cytometry: 1X10 6 Rat splenocytes were surface-stained with FITC Rabbit IgG isotype control (A25616,5 µl/Test,left) or FITC Rabbit anti-Rat CD45 mAb (A28531,0.5 µg,right).
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