DUSP1/MKP1 Rabbit pAb, Unconjugated, Polyclonal

Product Overview

• Article Name: DUSP1/MKP1 Rabbit pAb, Unconjugated, Polyclonal
• Biozol Catalog Number: ABB-A2919
• Supplier Catalog Number: A2919
• Alternative Catalog Number: ABB-A2919-500UL,ABB-A2919-20UL,ABB-A2919-100UL,ABB-A2919-1000UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: HVH1, MKP1, CL100, MKP-1, PTPN10, DUSP1/MKP1

Product Description

The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.

Product Properties

• Clonality: Polyclonal
• Molecular Weight: 39kDa
• NCBI: 1843
• UniProt: P28562
• Purity: Affinity purification
• Sequence: MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESG
• Target: DUSP1
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: WB,1:100 - 1:500|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Signal Transduction,Kinase,MAPK-Erk Signaling Pathway,MAPK-JNK Signaling Pathway. Shipping: Ice Bag

Images

Western blot analysis of lysates from Rat brain, using DUSP1/MKP1 Rabbit pAb (A2919) at 1:500 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 180s.