COX1/PTGS1 Rabbit mAb, Unconjugated, Monoclonal

Product Overview

• Article Name: COX1/PTGS1 Rabbit mAb, Unconjugated, Monoclonal
• Biozol Catalog Number: ABB-A4301
• Supplier Catalog Number: A4301
• Alternative Catalog Number: ABB-A4301-100UL,ABB-A4301-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: COX1, COX3, PHS1, PCOX1, PES-1, PGHS1, PTGHS, PGG/HS, PGHS-1, COX1/PTGS1

Product Description

This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 69 kDa
• NCBI: 5742
• UniProt: P23219
• Purity: Affinity purification
• Target: PTGS1

Application Notes

• Application Dilute: WB,1:1000 - 1:3000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse. ResearchArea: Cancer,Signal Transduction,Endocrine Metabolism,Lipid Metabolism,Immunology Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,Cardiovascular,Blood,Heart,Cardiovascular diseases,Heart disease. Shipping: Ice Bag

Images

Western blot analysis of various lysates using COX1/PTGS1 Rabbit mAb (A4301) at 1:1000 dilutionincubated overnight at 4°C.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Negative control (NC): MOLT-4.
Exposure time: 10 s.