PSA/KLK3 Rabbit mAb, Unconjugated, Monoclonal

Product Overview

• Article Name: PSA/KLK3 Rabbit mAb, Unconjugated, Monoclonal
• Biozol Catalog Number: ABB-A4355
• Supplier Catalog Number: A4355
• Alternative Catalog Number: ABB-A4355-100UL,ABB-A4355-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: APS, PSA, hK3, KLK2A1, PSA/KLK3

Product Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 29kDa
• NCBI: 354
• UniProt: P07288
• Purity: Affinity purification
• Target: KLK3

Application Notes

• Application Dilute: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human. ResearchArea: Cancer,Tumor immunology,Tumor-associated antigens,Tumor biomarkers,Signal Transduction,Cell Biology Developmental Biology,Cell Adhesion,Cytoskeleton,Extracellular Matrix,Immunology Inflammation,Neuroscience, Cell Type Marker,Cardiovascular,Angiogenesis. Shipping: Ice Bag

Images

Western blot analysis of lysates from LNCaP cells, using PSA/KLK3 Rabbit mAb (A4355) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.