Bcl10 Rabbit mAb, Unconjugated, Monoclonal

Product Overview

• Article Name: Bcl10 Rabbit mAb, Unconjugated, Monoclonal
• Biozol Catalog Number: ABB-A4520
• Supplier Catalog Number: A4520
• Alternative Catalog Number: ABB-A4520-100UL,ABB-A4520-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: CLAP, mE10, CIPER, IMD37, c-E10, CARMEN, Bcl10

Product Description

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 26kDa
• NCBI: 8915
• UniProt: O95999
• Purity: Affinity purification
• Target: BCL10

Application Notes

• Application Dilute: WB,1:1000 - 1:4000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human. ResearchArea: Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology Developmental Biology,Apoptosis,Caspases,Endocrine Metabolism,Immunology Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway. Shipping: Ice Bag

Images

Western blot analysis of various lysates using Bcl10 Rabbit mAb (A4520) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.