GluR4/GluA4/GRIA4 Rabbit mAb, Unconjugated, Monoclonal

Product Overview

• Article Name: GluR4/GluA4/GRIA4 Rabbit mAb, Unconjugated, Monoclonal
• Biozol Catalog Number: ABB-A4593
• Supplier Catalog Number: A4593
• Alternative Catalog Number: ABB-A4593-100UL,ABB-A4593-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: GLUR4, GLURD, GluA4, GLUR4C, NEDSGA, GluA4-ATD, GluR4/GluA4/GRIA4

Product Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA, R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 101kDa
• NCBI: 2893
• UniProt: P48058
• Purity: Affinity purification
• Target: GRIA4

Application Notes

• Application Dilute: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Mouse,Rat. ResearchArea: Signal Transduction,G protein signaling,G-Protein-Coupled ReceptorsGPCR,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Dopamine Signaling in Parkinsons Disease. Shipping: Ice Bag

Images

Western blot analysis of various lysates using GluR4/GluA4/GRIA4Rabbit mAb (A4593) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.