BMAL1 Rabbit mAb, Unconjugated, Monoclonal

Product Overview

• Article Name: BMAL1 Rabbit mAb, Unconjugated, Monoclonal
• Biozol Catalog Number: ABB-A4714
• Supplier Catalog Number: A4714
• Alternative Catalog Number: ABB-A4714-100UL,ABB-A4714-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: TIC, JAP3, MOP3, ARNTL, PASD3, ARNTL1, BMAL1c, bHLHe5, BMAL1

Product Description

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 69kDa
• NCBI: 406
• UniProt: O00327
• Purity: Affinity purification
• Target: BMAL1

Application Notes

• Application Dilute: WB,1:1000 - 1:6000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Epigenetics Nuclear Signaling,Transcription Factors,Cancer,Endocrine Metabolism,Lipid Metabolism,Cholesterol Metabolism,Neuroscience,Cardiovascular,Blood,Heart,Lipids. Shipping: Ice Bag

Images

Western blot analysis of various lysates using BMAL1 Rabbit mAb (A4714) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 3s.