ABCC8 Rabbit pAb, Unconjugated

Product Overview

• Article Name: ABCC8 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-A8456
• Supplier Catalog Number: A8456
• Alternative Catalog Number: ABB-A8456-100UL, ABB-A8456-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: HI, SUR, HHF1, MRP8, PHHI, SUR1, ABC36, HRINS, PNDM3, TNDM2, SUR1delta2, ABCC8

Product Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.

Product Properties

• Molecular Weight: 177kDa
• NCBI: 6833
• UniProt: Q09428
• Purity: Affinity purification
• Target: ABCC8

Application Notes

• Application Dilute: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Mouse, ResearchArea: Cancer,Signal Transduction,Endocrine Metabolism,Drug metabolism,Endocrine and metabolic diseases,Diabetes,Cardiovascular,Heart,Cardiac arrhythmias,Cardiovascular diseases,Heart disease.

Images

Western blot analysis of lysates from mouse pancreas, using ABCC8 Rabbit pAb (A8456) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 60s.