Calpain small subunit 1 Rabbit mAb, Unconjugated

Product Overview

• Article Name: Calpain small subunit 1 Rabbit mAb, Unconjugated
• Biozol Catalog Number: ABB-A8859
• Supplier Catalog Number: A8859
• Alternative Catalog Number: ABB-A8859-20UL, ABB-A8859-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4, Calpain small subunit 1

Product Description

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.

Product Properties

• Molecular Weight: 28kDa
• NCBI: 826
• UniProt: P04632
• Purity: Affinity purification
• Target: CAPNS1

Application Notes

• Application Dilute: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse,Rat, ResearchArea: Signal Transduction,Immunology Inflammation,T Cell Receptor Signaling Pathway,Neuroscience,Calcium Signaling.

Images

Western blot analysis of various lysates using Calpain small subunit 1 Rabbit mAb (A8859) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time: 3min.