FHIT Rabbit mAb, Unconjugated

Product Overview

• Article Name: FHIT Rabbit mAb, Unconjugated
• Biozol Catalog Number: ABB-A9072
• Supplier Catalog Number: A9072
• Alternative Catalog Number: ABB-A9072-20UL, ABB-A9072-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: FRA3B, AP3Aase, FHIT

Product Description

The protein encoded by this gene is a P1-P3-bis(5-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.

Product Properties

• Molecular Weight: 17kDa
• NCBI: 2272
• UniProt: P49789
• Purity: Affinity purification
• Target: FHIT

Application Notes

• Application Dilute: WB,1:1000 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse,Rat, ResearchArea: Epigenetics Nuclear Signaling,Cancer,Tumor suppressors.

Images

Western blot analysis of various lysates using FHIT Rabbit mAb (A9072) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 60s.