Phospho-MEK2-T394 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-MEK2-T394 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP0121
• Supplier Catalog Number: AP0121
• Alternative Catalog Number: ABB-AP0121-100UL, ABB-AP0121-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: CFC4, MEK2, MKK2, MAPKK2, PRKMK2, Phospho-MEK2-T394

Product Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Product Properties

• Molecular Weight: 44kDa
• NCBI: 5605
• UniProt: P36507
• Purity: Affinity purification
• Target: MAP2K2

Application Notes

• Application Dilute: WB,1:500 - 1:2000|IF/ICC,1:100 - 1:200
• Application Notes: Cross-Reactivity: Human, ResearchArea: Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors Signaling to MAPK Erk,Kinase,Serine threonine kinases,Tyrosine kinases,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Cytoskeleton,Actins,ESC Pluripotency and Differentiation,Endocrine Metabolism,Insulin Receptor Signaling Pathway,Warburg Effect,Immunology Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Jak-Stat-IL-6 Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Cardiovascular,Angiogenesis.

Images

Western blot analysis of lysates from HepG2 cells using Phospho-MEK2-T394 Rabbit pAb (AP0121).
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.